About Us

Research in the Howell group encompasses projects involving method development, total synthesis and the interface of chemistry and biology.  The two main foci are the synthesis and exploitation of unusual strained heterocycles and the preparation of glycosphingolipids that activate natural killer T (NKT) cells. (more...)


The Group


  • Check out our latest publications
    Exciting news: our current group member, Pascal, published his work on chemical probe development in ChemBioChem. Additionally, our former group member, Santosh, published an article in ACS Chemical Biology about his study on the potent stimulation of iNKT cells and anti-tumor immunity in humanized mouse model by modified KRN7000. Congratulations, guys!
    Posted on December 22, 2020
  • ACS-CVS C-H Activation Symposium
    Past and current members of the Howell group had a great time at the ACS-CVS symposium on Solutions to Challenging C-C Bond formation.  The first talk was given by former member Christian Malapit, who is currently undergoing a postdoc in Melanie Sanford’s lab at the University of Michigan. He did a great job, Congrats Christian! […]
    Posted on September 25, 2018
  • 2018 Spring Graduation
    Congratulations to all those who recently graduated from UConn! It was wonderful having the Howell group’s very own Kendricks Lao back to walk for his PhD.  Good luck with all your future endeavors Ken!  
    Posted on May 9, 2018
  • Congrats to the 2 newest doctors of the Howell Group!
    Kevin and Nicole both successfully completed their PhD defenses, and both are moving on to great things.  Nicole accepted a position as a Technical Specialist at the law firm Lathrop Gage.  Kevin is shortly starting a post-doctoral position in the group of Dr. Joseph Ready at UT Southwestern in Dallas, Texas.  Congrats again!
    Posted on February 6, 2018